![]() The side effects of topical lidocaine are very minimal, but include skin problems (such as irritation and redness). No comparison was made with other medications that are in current use for the treatment of postherpetic neuralgia. Two studies provided data on pain relief amongst patients with postherpetic neuralgia, and they showed some improvement in pain when topical lidocaine was compared to a placebo. This review found three small studies involving 182 topical lidocaine treated participants and 132 control participants using lidocaine for patients with postherpetic neuralgia. Local anaesthetics (such as lidocaine) can reduce the sensation of pain that is transmitted through nerves, and allow pain relief in patients with postherpetic neuralgia. Postherpetic neuralgia is a long‐lasting pain disorder that causes pain from stimuli that are not normally painful. Topical lidocaine may benefit some patients on an individual basis though there is stronger evidence for the use of other drugs. The latter figure is high and the authors of the study suggest that the sample had been contaminated during the assay procedure. The highest recorded blood lidocaine concentration varied between 59 ng/ml and 431 ng/ml between studies. There were a similar number of adverse skin reactions in both treatment and placebo groups. There was a statistical difference between the groups for the secondary outcome measure of mean VAS score reduction (P = 0.03), but this was only for a single small study. Topical lidocaine relieved pain better than placebo (P = 0.003). The largest study published as an abstract compared topical lidocaine patch to a placebo patch and accounted for 150 of the 314 participants (48%).Ī meta‐analysis combining two studies identified a significant difference between topical lidocaine and control groups for the primary outcome measure: a mean improvement in pain relief according to a pain relief scale. Two studies gave data on pain relief, and the remaining study provided data on secondary outcome measures. Conclusions: This meta-analysis suggests that topical lidocaine-prilocaine cream gives comparable results in reducing pain during perineal repair after vaginal delivery.Įpisiotomy lidocaine-prilocaine local anesthesia perineal tear vaginal delivery.In the original review three studies involving 182 topical lidocaine treated participants and 132 control participants were included. The pooled analysis of the outcome "duration of repair" showed the significantly shorter duration of repair in EMLA cream users ( n = 92) than local infiltration anesthesia ( n = 95) (1.72 min 95% CI (-2.76 to -0.67), p =. Regarding patient satisfaction, an overall analysis of three studies showed significant results favoring EMLA cream group users (WMD 4.65 95% CI (1.96-11.03), p =. Furthermore, the use of additional analgesia showed no statistically significant difference between the two groups (WMD 1.34 95% CI (0.66-2.71), p =. Results: Pooled analysis of result in "pain score" was insignificant between the two groups (WMD -1.11 95% CI (-2.55 to 0.33) p =. Otherwise, the fixed effect meta-analysis was used when there was no significant heterogeneity. When heterogeneity was significant, a random-effects model was used for meta-analysis. Statistical heterogeneity between studies was assessed by the Higgins chi-square and (I 2) statistics. The weighted mean difference (WMD) and 95% confidence interval (CI) was calculated. ![]() ![]() Data extraction: Two researchers independently extracted the data from the individual articles and entered into RevMan software. Quality and risk of bias assessment was performed for all studies. Fifteen studies were identified of which four studies deemed eligible for this review. Methods of study selection: All randomized controlled trials assessing effect of lidocaine-prilocaine cream versus local infiltration anesthesia in relieving pain during repair of perineal trauma were considered for this meta-analysis. Data sources: Medline, Embase, Dynamed Plus, ScienceDirect, TRIP database, and the Cochrane Library were searched electronically from January 2006 to May 2018 for studies investigating the effect of lidocaine-prilocaine cream in relieving pain during repair of perineal trauma. Objective: The aim of this review is to assess the evidence of utilizing EMLA cream in comparison to local perineal infiltration anesthesia for pain control during perineal repair after vaginal delivery. ![]() Topical products as lidocaine-prilocaine (EMLA) cream is one of the suggested methods, but still there is lack of evidence with regard to its efficacy and safety. When repair of perineal trauma is required, adequate analgesics must be obtained. Background: Perineal trauma is a common problem that may affect women during vaginal delivery this trauma can be either spontaneous (tear) or intentional (episiotomy). ![]()
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